Inflammation of pancreas or pancreatitis is common reason of of pain in pancreas. For details, visit this link.
What Makes The Pancreas Hurt?
Pancreatitis, and it is extremely painful. It is usually attributed to drinking every day, but a bad gallbladder is another reason, and swollen duodenal too. Pancreatitis requires hospitalization, nausea and pain meds, IV fluids, and nothing by mouth.