Pain relief medications such as aspirin, acetaminophen, ibuprofen, neproxen , diclofenac, and phenybutazone ,Anti-seizure medications such as phenytoin, valproic acid, carbamazepine , and phenobarbital, Antibiotics such as the tetracyclines, sulfonamides, isoniazid , sulfamethoxazole, trimethoprim, nitrofurantoin, Cholesterol lowering drugs such as statins, and niacin, Cardiovascular drugs such as amiodarone, hydralazine, quinidine, etc. Anti-depressant drugs of the tricyclic type. Methotrexate may cause liver damage leading to increase in liver enzymes.