This condition is manifested clinically by insidious onset of gross generalized edema, and by proteinuria, associated with low plasma proteins. The disease is also known as 'Lipoid Nephrosis, Subacute Nephritis).
Pure nephrosis or lipoid nephrosis starts in children below the age of five years. Nephrotic syndrome, associated with a variety of other kidney conditions is seen in older children.
Both kidneys are affected and appear very pale and swollen. The child appears to be irritable, listless and pale, with no interest in food. Edema affects face, legs and abdomen leading to weight gain. Urine output is reduced and proteinuria is present. Hematuria may occur and usually indicates a poor prognosis. Blood pressure initially is normal.
Daily testing of urine and estimation of the amount of protein lost in the urine. Frequent laboratory examination of the urine for the cells and casts, also culture for evidence of infection in the urine is required. Blood investigations needed will include a total blood picture, urea levels which are normal until the terminal stages, total plasma proteins which are low, serum cholesterol which is usually raised, and the ESR which may be elevated. Serum electrolytes should be estimated frequently. Renal biopsy may be performed to confirm the diagnosis if there is nay doubt about this.
Pure nephrosis or lipoid nephrosis starts in children below the age of five years. Nephrotic syndrome, associated with a variety of other kidney conditions is seen in older children.
Both kidneys are affected and appear very pale and swollen. The child appears to be irritable, listless and pale, with no interest in food. Edema affects face, legs and abdomen leading to weight gain. Urine output is reduced and proteinuria is present. Hematuria may occur and usually indicates a poor prognosis. Blood pressure initially is normal.
Daily testing of urine and estimation of the amount of protein lost in the urine. Frequent laboratory examination of the urine for the cells and casts, also culture for evidence of infection in the urine is required. Blood investigations needed will include a total blood picture, urea levels which are normal until the terminal stages, total plasma proteins which are low, serum cholesterol which is usually raised, and the ESR which may be elevated. Serum electrolytes should be estimated frequently. Renal biopsy may be performed to confirm the diagnosis if there is nay doubt about this.